Futaba Yoshioka used to be an attractive and popular middle-schooler—well liked by the opposite sex, but ostracized by the girls. Nevertheless, she was able to brush all that off, because the only opinion that truly mattered to her was that of Kou Tanaka, a classmate with whom she shared a shelter from rain once, followed by quite a few other precious and significant memories. She even succeeded at making plans to meet with the quiet and innocent boy at the summer festival, but a simple misunderstanding, and Tanaka's subsequent disappearance, left her walking the halls of her school friendless. Now in high school, Futaba is not your typical adolescent girl. Determined to become a class favorite this time, she avoids all unwanted attention and, instead of acting cute and feminine, only stands out through her tomboyish behavior and disheveled look. But still, her world is soon turned upside down when the only boy she ever liked unexpectedly comes into her life once again—except he goes by the name of Kou Mabuchi now, and it is not his name alone that has gone through a sea change. [Written by MAL Rewrite]

Kino, a 15-year-old traveler, forms a bond with Hermes, a talking motorcycle. Together, they wander the lands and venture through various countries and places, despite having no clear idea of what to expect. After all, life is a journey filled with the unknown. Throughout their journeys, they encounter different kinds of customs, from the morally gray to tragic and fascinating. They also meet many people: some who live to work, some who live to make others happy, and some who live to chase their dreams. Thus, in every country they visit, there is always something to learn from the way people carry out their lives. It is not up to Kino or Hermes to decide whether these asserted values are wrong or right, as they merely assume the roles of observers within this small world. They do not attempt to change or influence the places they visit, despite how absurd these values would appear. That's because in one way or another, they believe things are fine as they are, and that "the world is not beautiful; therefore, it is." [Written by MAL Rewrite]

"Mushi": the most basic forms of life in the world. They exist without any goals or purposes aside from simply "being." They are beyond the shackles of the words "good" and "evil." Mushi can exist in countless forms and are capable of mimicking things from the natural world such as plants, diseases, and even phenomena like rainbows. This is, however, just a vague definition of these entities that inhabit the vibrant world of Mushishi, as to even call them a form of life would be an oversimplification. Detailed information on Mushi is scarce because the majority of humans are unaware of their existence. So what are Mushi and why do they exist? This is the question that a "Mushishi," Ginko, ponders constantly. Mushishi are those who research Mushi in hopes of understanding their place in the world's hierarchy of life. Ginko chases rumors of occurrences that could be tied to Mushi, all for the sake of finding an answer. It could, after all, lead to the meaning of life itself. [Written by MAL Rewrite]

As Kobayashi sets off for another day at work, she opens her apartment door only to be met by an unusually frightening sight—the head of a dragon, staring at her from across the balcony. The dragon immediately transforms into a cute, busty, and energetic young girl dressed in a maid outfit, introducing herself as Tooru. It turns out that the stoic programmer had come across the dragon the previous night on a drunken excursion to the mountains, and since the mythical beast had nowhere else to go, she had offered the creature a place to stay in her home. Thus, Tooru had arrived to cash in on the offer, ready to repay her savior's kindness by working as her personal maidservant. Though deeply regretful of her words and hesitant to follow through on her promise, a mix of guilt and Tooru's incredible dragon abilities convinces Kobayashi to take the girl in. Despite being extremely efficient at her job, the maid's unorthodox methods of housekeeping often end up horrifying Kobayashi and at times bring more trouble than help. Furthermore, the circumstances behind the dragon's arrival on Earth seem to be much more complicated than at first glance, as Tooru bears some heavy emotions and painful memories. To top it all off, Tooru's presence ends up attracting several other mythical beings to her new home, bringing in a host of eccentric personalities. Although Kobayashi makes her best effort to handle the crazy situation that she has found herself in, nothing has prepared her for this new life with a dragon maid. [Written by MAL Rewrite]