Using the fossil of the Legendary Pokémon Mew, Team Rocket has created the first successful Pokémon clone. Named Mewtwo, the man-made Pokémon quickly becomes upset with the circumstances of its creation and goes on a rampage. It is soon approached by Sakaki, the leader of Team Rocket, and is manipulated into committing evil acts. Repulsed by the tricks of mankind and the cruelties it has suffered, Mewtwo isolates itself from everyone and plots against humans whilst trying to discover its true purpose in life. Disguising as the world's strongest Pokémon trainer, Mewtwo draws in the region's most powerful trainers who want to fight the new, mysterious opponent. With the fate of the world at stake, renowned trainers Satoshi, Takeshi, and Kasumi must battle against Mewtwo and defeat it before it brings about the downfall of humanity. A team of scientists use the DNA of a rare Pokemon, Mew, to create the world's strongest Pokemon, Mewtwo. Not wanting to be used as an experiment, Mewtwo uses its psychic powers in a violent rage to destroy the scientists who created it. Mewtwo then tries to learn how to focus his powers with the aid of Giovanni, the man who funded the scientists' operations, but discovers that it is being used again. So Mewtwo decides to find its own purpose in life, and carry out its revenge on humans by destroying life on earth by using a deadly storm. Ash Ketchum and a group of other Pokemon Trainers are summoned by Mewtwo to have a battle with it, but they soon discover that they're only being invited so Mewtwo can clone their Pokemon for it's own purposes. Ash then tries to find a way to stop Mewtwo's plot before it can be carried out.